Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2021  |  Volume : 19  |  Issue : 4  |  Page : 264-268

Long-term hydrochlorothiazide use and risk of cutaneous neoplasms

1 Department of Pharmacy, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India
3 Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India
4 Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. Heber Rew Bright
Department of Pharmacy, Christian Medical College, Vellore - 632 004, Tamil Nadu
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cmi.cmi_36_21

Rights and Permissions

Background: Hydrochlorothiazide is a diuretic commonly used in the treatment of hypertension. Recently, there have been published reports of hydrochlorothiazide-induced cutaneous neoplasms among Caucasians. We therefore investigated the risk for cutaneous neoplasms with hydrochlorothiazide use among the Indian population. Methods: We conducted a case–control study comparing hydrochlorothiazide use among patients diagnosed with cutaneous neoplasms between 2008 and 2017. Patients who underwent skin biopsy and had a pathological diagnosis of either nonmelanoma skin cancers or mycosis fungoides were matched with control patients without a skin cancer diagnosis in a 1:1 ratio. Hydrochlorothiazide use, its dose, and duration of use were compared between the groups. Odds ratio (OR) and 95% confidence intervals (CIs) for cutaneous neoplasms were calculated. Results: Among 90 patients in each group, 7 cases (7.78%) and 7 controls (7.78%) had hydrochlorothiazide exposure for at least 30 days, up to 1 year before cancer diagnosis (OR 1.0, 95% CI 0.34–2.98). Cumulative dose (P = 0.242) and duration of hydrochlorothiazide use (P = 0.08) did not differ between cases (n = 6) and controls (n = 5). There was a trend toward increasing risk of cutaneous neoplasms with high cumulative dose (≥25,000 mg) of hydrochlorothiazide (57.14% vs. 14.29%). The groups were similar with respect to comorbidities and concomitant drug intake; however, cases included more homemakers than controls (P = 0.008). Among hydrochlorothiazide-exposed cases, the body site of basal cell carcinoma involvement was predominantly the head/neck (n = 2; 66.67%), followed by the trunk (n = 1; 33.33%). Conclusion: The current findings did not find an association between long-term hydrochlorothiazide use and occurrence of cutaneous neoplasms.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded142    
    Comments [Add]    

Recommend this journal