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Year : 2020  |  Volume : 18  |  Issue : 4  |  Page : 312-316

Choline-stabilized orthosilicic acid and bone health

Department of Orthopaedics, Mukund Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Ram Prabhoo
Mukund Nagar Co Operative Housing Society, J B Nagar, Andheri Kurla Road, Andheri East, Landmark, Near Marol Pipe Line, Mumbai - 400 059, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cmi.cmi_78_20

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Certain trace elements play a very important role in bone health. Silicon is one such essential trace element required for bone regeneration, bone mineral density, and overall bone biology. Deficiency of silicon is associated with bone resorption rate, decreased osteoblastogenesis, increased osteoclastogenesis, reduced collagen, and glycosaminoglycan formation, suggesting a definite role of silicon in osteoporosis. Choline-stabilized orthosilicic acid (ch-OSA®) is a stable and bioavailable form of silicon. Due to its stable nature, it cannot be converted into nonabsorbable silica (polymerized) gel form. ch-OSA® is known to stimulate the enzymatic pathway of endogenous collagen synthesis. Silicon supplementation stimulates osteoblasts, osteoblastic differentiation, osteopontin, osteocalcin, alkaline phosphatase, and bone matrix mineralization. It inhibits bone resorption by reducing the surface area of osteoclasts. ch-OSA® has shown synergistic effects with calcium and Vitamin D, indicating its potential role in the management of osteoporosis. The aim of this review is to outline the importance of ch-OSA® on bone health.

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